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Chlorsig Eye Drops, Chloramphenicol For Bacterial Conjunctivitis And Superficial Eye InfectionsChlorsig Eye Drops contain chloramphenicol and can be used to treat Bacterial Conjunctivitis and other superficial eye infections caused by bacterial infection.Medicine Classification: Restricted Medicine. Indications For the treatment of bacterial conjunctivitis and other superficial ocular infections caused by chloramphenicol-sensitive organisms. "What is chloramphenicol?" Chloramphenicol is a broad spectrum antibiotic originally isolated from Streptomyces venezuelae. It is primarily bacteriostatic and acts by inhibition of protein synthesis by interfering with the transfer of activated amino acids from soluble RNA to ribosomes. "How Do I use Chlorsig Eye Drops?" Instil 1 or 2 drops in the affected eye(s) every two to six hours for two to three days. The interval between applications may then be increased. Discard solution within one month of opening container.The systemic absorption of CHLORSIG EYE DROPS can be minimised by applying gentle pressure on the tear-duct for approximately one minute immediately after application. "Are There Any Contraindications For Chlorsig Eye Drops?" Chloramphenicol is contraindicated in individuals with a history of hypersensitivity to any excipients and/or toxic reaction to the medicine. "Are There Any Warnings and Precautions For Chlorsig Eye Drops?" Bone marrow hypoplasia, including aplastic anaemia and death, has been rarely reported following local application of chloramphenicol. Chloramphenicol should not be used when less potentially dangerous agents would be expected to provide effective treatment. Ophthalmic agents may retard corneal wound healing. The use of this antibiotic, as with other antibiotics, may result in the overgrowth of non-susceptible organisms, including fungi. If infections caused by non-susceptible organisms appear during therapy, its use should be discontinued and appropriate measures should be taken. In all serious infections, the topical use of chloramphenicol should be supplemented by appropriate systemic medication. The mechanism for the irreversible aplastic anaemia following ophthalmic use of chloramphenicol has not been established. "Can I Use Chlorsig Eye Drops If I Am Pregnant?" Chloramphenicol enters the foetal circulation, and if given to the mother shortly before parturition, may cause the gray baby syndrome, with cyanosis and hypothermia, owing to the limited glucoronidating capacity of the newborn infant's liver. Chloramphenicol treatment should, therefore, be avoided during the last week before parturition and during breast feeding. "Are There Any Adverse Reactions To Chlorsig Eye Drops?" Blood dyscrasias have been reported in association with the use of chloramphenicol (see Warnings and Precautions ). Chloramphenicol is absorbed systemically from the eye, and toxicity has been reported following chronic exposure. Dose related toxicity following a single ocular exposure is unlikely. Local irritation with the ophthalmic form may include subjective symptoms of itching or burning. More serious side effects such as angioneurotic oedema; anaphylaxis, urticaria, fever, vesicular and maculopapular dermatitis have been reported in patients sensitive to chloramphenicol and are causes for discontinuing the medication. Similar sensitivity reactions to other materials in topical preparations also may occur. In Case Of Overdosage Accidental ingestion of the medicine is unlikely to cause any toxicity due to low content of antibiotic. CHLORSIG EYE DROPS contains 18.80mg/ml of borax/boric acid as buffer with less than 0.13mg/ml of sodium hydroxide. If the eye drops are accidentally ingested by infants or young children, Poisons Information Centre should be contacted. The medication should be kept out of reach of children. Treatment Using Chlorsig Eye Drops If irritation, pain, swelling, lacrimation or photophobia occur after undesired eye contact, the exposed eye(s) should be irrigated with copious amounts of room temperature water for at least 15 minutes. If symptoms persist after 15 minutes of irrigation, an ophthalmological examination should be considered. CHLORSIG EYE DROPS and CHLORSIG EYE OINTMENT contain the following excipients: Chlorsig Eye Drops Chlorsig Eye Ointment, Phenylmercuric acetate Paraffin - liquid, Boric acid Paraffin - soft white, Borax Wool fat, Hypromellose, Sodium hydroxide, Water - freshly distilled, Molecular formula is C11H12Cl2N2O5 and a molecular weight of 323.1. ---FB FB---
 
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